Again hard to say. If compression is good, oil pressure is good, and it doesn't overheat or hasn't been overheated then you're good.
Also, on the supercharged models the supercharger needs to be rebuilt every 100hrs. If it fails, you get a whole mess of things that go in your motor and block the oil pickup resulting in loss of oil pressure which almost always causes catastrophic engine failure.
Another thing to keep in mind is cost of rebuilding one. About 2 to 2.5 times the cost of a 2 stroke assuming you're not doing the work yourself.
With all that said I'd take a 4 stroke any day over a 2 stroke.